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KMID : 0363620120330020047
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Journal of Korean Oriental Medicine
2012 Volume.33 No. 2 p.47 ~ p.55
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Anti-Myelosuppression Effects of Korean Red Ginseng in SD Rat Injected with 5-fluorouracil
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Park Hye-Jung
Han Jong-Min
Kim Hyeong-Geug
Cho Min-Kyung
Lee Jin-Seok
Son Chang-Gue
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Abstract
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Objectives: This study aimed to investigate the preventive effect of red ginseng (RG) on 5-fluorouracil (5-FU)-induced side effects focusing on myelosuppression.
Methods: Rats (n = 50) were divided into five groups, nave, control (ip, 5-FU injection of 150 mg/kg), and RG pre-treatment (po, 25, 50 and 100 mg/kg for 5 days before 5-FU injection). On the 7th day after 5-FU injection, we evaluated the effects using peripheral hematological parameters, colony-forming assay, cytokine levels and histopathological finding.
Results: The peripheral white blood cell and the differential count were dramatically suppressed by 5-FU, while RG (50 and 100 mg/kg) treatment significantly improved total white blood cell, neutrophil, lymphocyte and platelet counts. Also, RG (100 mg/kg) pre-treatment significantly increased the number of CFU-GM colony compared with the control group. RG pre-treatment also ameliorated the histopathological damage in bone marrow, spleen, stomach and small intestine tissue.
Conclusions: These results demonstrate that Korean RG has preventive effects against 5-FU-induced myelotoxicity and gastrointestinal damage.
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KEYWORD
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Red ginseng , 5-fluorouracil , Myelosuppression , Side effect , Chemotherapy
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